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Genes such as OLFM3 (olfactomedin 3, involved in brain and retina differentiation), SLC17A6 (vesicular glutamate transporter 2, important for synaptic plasticity), CNTN6 (contactin 6, associated with axonal formation), and IRF6 (interferon regulatory factor 6, relevant to apoptosis regulation) were upregulated in treated rats

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Because we know that in animal studies, five days of pure darkness dramatically increases the amount of melanopsin in the retinas